Donald Jerome Driver (born February 2, 1975 in Houston, Texas) is an American football wide receiver who currently plays for the Green Bay Packers of the NFL. The Packers chose him in the 1999 NFL Draft with a seventh round selection (213th pick overall) out of Alcorn State University. Donald Driver is the Green Bay Packers' most versatile and agile pass catcher. "Donald is able to play all our positions. He is very explosive, and he's shown plenty of big-play ability", …

Steve LaTreal McNair (born February 14, 1973), nicknamed Air McNair, is an American professional football player who spent 11 years as a quarterback for the Tennessee Titans (formerly Houston Oilers), until he was traded in June 2006 to the Baltimore Ravens.

Louis Edward Green (born September 23, 1979 in Vicksburg, Mississippi) is a football player. A linebacker who plays for the Denver Broncos, he previously went to Alcorn State University. On February 19, 2007, the Broncos resigned Green to a 3-year, $2.5 million contract with a $300,000 signing bonus.

Chad Slaughter (born June 4, 1978 in Dallas, Texas) is currently playing offensive tackle for the Oakland Raiders in the National Football League. He played college football at Alcorn State University.

Lawrence Pillers (born 1952) is a former American Football defensive end who played for the New York Jets, the San Francisco 49ers and the Atlanta Falcons in a ten year career that lasted from 1976 to 1985 in the National Football League. Pillers played college football at Alcorn State University and was drafted in the eleven round of the 1976 NFL Draft by the Jets. He was a member of the San Francisco 49ers Super Bowl XVI and Super Bowl XIX winning teams.

Leslie Antonio Frazier (born April 3, 1959 in Columbus, Mississippi) was a cornerback/safety in the National Football League for the Chicago Bears. He is currently the Defensive Coordinator for the Minnesota Vikings.

Roynell Young (born December 1, 1957 in New Orleans, Louisiana), is a former professional American football safety and cornerback who played for the Philadelphia Eagles his entire NFL career from 1980 through 1988. Young was selected by the Eagles from the Alcorn State University in the 1st round (23rd overall) of the 1980 NFL Draft. In his rookie year he played in Super Bowl XV and was selected to the Pro Bowl in his second season.

David Washington (born 1948) is a former American Football linebacker who played for five teams in an eleven year career that lasted from 1970 to 1980 in the National Football League. Washington played college football at Alcorn State University and was drafted in the ninth round of the 1970 NFL Draft by the Denver Broncos. He was a one time Pro Bowler in 1976.

Jimmie Giles (born November 8, 1954 in Natchez, Mississippi), was a former American professional football player who was selected by the Houston Oilers in the 3rd round of the 1977 NFL Draft. A 6'3", 238 lbs. tight end from Alcorn State University, Giles played in 13 NFL seasons from 1977-1989. A four-time Pro Bowl selection, Giles's career flourished as a member of the Tampa Bay Buccaneers during the early and mid 1980's.

Willie Alexander (born in 1949) is a former professional American Football player who played defensive back for the National Football League's Houston Oilers from 1971 - 1979. Before his professional career, Alexander played for Alcorn State University.

Otis Wonsley (born August 13, 1957 in Pascagoula, Mississippi) was an American football running back who played for the Washington Redskins of the NFL. He played college football for Alcorn State University.

Issiac Holt (born October 4, 1962 in Birmingham, Alabama) is a former professional American football player who played cornerback for eight seasons for the Minnesota Vikings and Dallas Cowboys.

Medgar Wiley Evers (July 2, 1925 - June 12, 1963) was an African American civil rights activist from Mississippi.

Torrance Small (born September 4, 1970 in Tampa, Florida) is a former professional American football player who played wide receiver for ten seasons for the New Orleans Saints, St. Louis Rams, Indianapolis Colts, Philadelphia Eagles, and New England Patriots.

Larry Watkins, born October 5, 1946 in Bessemer, Alabama is a graduate from Alcorn State University, played professional football in the NFL from 1969 to 1977.