Pontiac or Obwandiyag, was an Ottawa leader who became famous for his role in Pontiac's Rebellion (1763–1766), an American Indian struggle against the British military occupation of the Great Lakes region following the British victory in the French and Indian War. Historians disagree about Pontiac's importance in the war that bears his name. Nineteenth century accounts portrayed him as the mastermind and leader of the revolt, …

Henry Gladwin was the British commander at Fort Detroit when it was besieged during Pontiac's Rebellion. Pontiac planned to take Fort Detroit, but Gladwin got wind of the plan. One romantic theory suggests that a Native American woman in love with Gladwin informed him of it. When Pontiac arrived at Fort Detroit, the British were ready. This made Pontiac retreat and set up a siege instead of taking over the fort.

Handsome Lake or Ganioda'yo (1735 - 10 August 1815) was a Seneca religious leader of the Iroquois people. He was also half-brother to Cornplanter. Before his emergence as a prophet, Handsome Lake fought in Pontiac's Rebellion (against the British) and the American Revolutionary War (against the Americans). After struggling with alcoholism and an apparently near-fatal illness in 1799, …

Guyasuta was an important leader of the Seneca people in the second half of the eighteenth century, playing a central role in the diplomacy and warfare of that era. His name is phonetically rendered as KayahsotaÃ, and the many spelling variations included Kiasutha, Kiasola, and Kiashuta. Guyasuta probably served as a scout for young George Washington in 1753, though he played a role in defeating the Braddock Expedition in 1755, …

Jeffery Amherst, 1st Baron Amherst KB (sometimes spelled Geoffrey, or Jeffrey, he himself spelled his name as Jeffery) (January 29, 1717 - August 3, 1797) served as an officer in the British Army.

John Gibson was the Territorial Secretary of the Indiana Territory. He served twice as acting governor of the territory. Gibson was born and raised in Lancaster, Pennsylvania. In 1758, he participated in the Forbes Expedition under General John Forbes against the French at Fort Duquesne and remained at Fort Pitt after the war to engage in trade with Native Americans.

Donald Campbell (d. 4 July 1763) was a British officer killed during the siege of Fort Detroit in Pontiac's Rebellion. He was taken prisoner during a flag of truce, and later killed and dismembered by Ojibwa chief Wasson, who ate his heart.

Sayenqueraghta was the war chief of the eastern Seneca tribe in the mid 18th century. His name in the Seneca language is phonetically rendered as Kaieñãkwaahtoñ, and was spelled in a variety of ways, including Gayahgwaahdoh and Kayenquaraghton. In historical records he is most often known as Sayenqueraghta (or Sayengaraghta), which was his name in the Mohawk language, or by nicknames such as Old Smoke or the Seneca King.

Charlot Kaské was a Shawnee war chief during Pontiac's Rebellion. Kaské's personal details were unusual for a Shawnee chief: he was a Catholic, his father was German, and his wife was an English captive brought up among the Shawnees. Kaské initially participated in Pontiac's Rebellion as an ally of Chief Pontiac in an effort to prevent the British from occupying the Illinois Country. As the war progressed and went badly for the American Indians, …

Shabonee (c. 1775-1859) was a chief of the Potawatomi and grandnephew of the Chief Pontiac. The son of an Ottawa warrior who had fought with Pontiac during Pontiac's Rebellion, Shabonee himself would become a lieutenant under Shawnee chieftain Tecumseh and, during the War of 1812, later participated in the Battle of the Thames where Tecumseh was killed. Embittered towards the British for their treatment following Tecumseh's death, …

James Potter, was a soldier, farmer and politician from Colonial- and Revolutionary-era Pennsylvania. He rose to the rank of brigadier general of Pennsylvania militia during the Revolutionary War, and served as Vice-President of Pennsylvania, 1781-1782.

Lawoughqua was a chief of the Shawnee. He was present when Colonel George Croghan visited the Kaskaskia and the Wabash Valley for trade purposes in 1765, near the end of Pontiac's Rebellion.

Major William Trent, born in Western Pennsylvania, was a soldier and merchant who played an important role in the early stages of the French and Indian War. He was a key local figure in the westward expansion across the Appalachian Mountains in the 1700s. He started his pioneer life being a soldier-of-fortune during the various local Indian wars in Pennsylvania and present day Maryland and West Virginia, and the French and Indian War.

Wasson (c. 1730 – c. 1790s) was an Ojibwa chief during the siege of Fort Detroit in Pontiac's Rebellion. Wasson led around 200 warriors, who joined Pontiac's forces on 31 May 1763, remaining as part of the siege until it was abandoned in the autumn. On 4 July, 1763 he killed captive Captain Donald Campbell (soldier) in revenge for the death of his nephew. From the following year until at least 1776 Wasson participated in a series of peace conferences, …