John Rolfe (c. 1585 - 1622) was one of the early English settlers of North America. He is credited with the first successful cultivation of tobacco as an export crop in the Colony of Virginia and is known as the husband of Pocahontas, daughter of the chief of the Powhatan Confederacy.

Chief Powhatan ("c." 1547-"c." 1618), whose proper name was Wahunsenacawh or (in seventeenth century English spelling) Wahunsunacock, was the leader of the Powhatan (also spelled "Powatan" and "Powhaten"), a powerful tribe of Native Americans, speaking an Algonquian language, who lived in Tenakomakah- which is now tidewater Virginia-at the time of the first English-Native encounters.

Queen Anne (ca. 1650 - ca. 1715) became the chief of the Pamunkey tribe when her aunt Cockacoeske died. Colonial Governor William Berkeley requested that Anne furnish warriors to the colonists during Bacon's Rebellion, but she refused on the grounds that her tribe had been neglected by the colonists for twenty years. She eventually relented when the colonists promised better treatment for her people. When Anne's village was attacked she barely escaped with her life, …

Don Luis (b. 1543? - 1646 ?) was a Native American who was the son of an Algonquian chief in an area which eventually became Virginia in the United States. He may have become the father of Wahunsonacock (better known as Chief Powhatan) or may possibly be the same individual later known as Opechancanough who became the Chief of the Powhatan Confederacy between the 1620s and 1640s, and a fierce opponent of the European settlers.

Sir Samuel Argall (baptized 4 December 1580 - c. 24 January 1626) was an English adventurer and naval officer. A sea captain, in 1609, Argall was the first to determine a shorter northern route from England across the Atlantic Ocean to the Virginia Colony based at Jamestown, and made numerous voyages to the New World. As a sea warrior, he is best-known for actions against the Powhatan Confederacy, successfully kidnapping the Chief's daughter, Pocahontas, …

Pocahontas was a Native American woman who married an Englishman, John Rolfe, and became a celebrity in London in the last year of her life. She was a daughter of Wahunsunacock (also known as Chief or Emperor Powhatan), who ruled an area encompassing almost all of the neighboring tribes in the Tidewater region of Virginia (called "Tenakomakah" at the time).

A weroance is an Algonquian word meaning tribal chief, leader, commander, or king, notably among the Powhatan confederacy of the Virginia coast and Chesapeake Bay region. The Powhatan Confederacy, encountered by the colonists of Jamestown and adjacent area of the Virginia Colony beginning in 1607, spoke an Algonquian language. Each tribe of the Powhatan Confederacy was led by its own weroance. In older texts, especially from the time of the early Jamestown settlers, …

John Smith, was an English soldier, sailor, and author. He is remembered for his role in establishing the first permanent English settlement in North America at Jamestown, Virginia, and his brief association with the Native American girl Pocahontas during an altercation with the Powhatan Confederacy, and her father, Chief Powhatan. He was a leader of the Virginia Colony (based at Jamestown) between 1607 and 1609, …

Opechancanough or Opchanacanough (1554?-1644) was a tribal chief of the Powhatan Confederacy of what is now Virginia in the United States, and its leader from 1618 until his death in 1644. His name meant "He whose Soul is White" in the Algonquin language.

Cockacoeske's husband/boyfriend was first married to Unity Croshaw, an independent minded woman who left him for his adultery, and some of whose descendants were the Dandridges, related to Martha Washington. Sporadic raids by Native Americans on the colony's frontier led Nathaniel Bacon to lead a popular uprising. The attackers had been the Doeg and Susquehannock Tribes but instead of attacking them, Bacon's men attacked the peaceful Pamunkey, Mattaponi, and Chislack Tribes.

Totopotomoi (ca. 1625-1656) was a grandson of a sister of Chief Powhatan, the father of Pocahontas. He became the Chief of the Pamunkey Tribe in 1649 when he succeeded Nectowance as chief sometime after the death of Opechancanough. He married Cockacoeske the daughter of Opechancanough. He held sway in New Kent and that part of New Kent which is now Hanover.

Uttamatomakkin, known as Tomocomo for short, was a Powhatan native shaman who accompanied Pocahontas on her visit to London in 1616. Little is known about Tomocomo's life before his visit to London. He is known to have been a shaman. He appears to have met Captain John Smith during Smith's time in Virginia, since Smith says that in London they "renewed their acquaintance". His wife, Matachanna, was Pocahontas's half-sister.

Nectowance (ca. 1600-1649) was the Weroance (chief) of the Pamunkey tribe following the death of his father Opechancanough. After his death he was succeeded by Totopotomoi as Weroance of the tribe. He signed a Treaty with the Colony of Virginia in 1645, at which time he was called by the English "King of the Indians."

Chanco, or Chauco, was a Native American emissary between Opechancanough, chief of the Pamunkey tribe, to and from the settlers of Jamestown in the Royal Colony of Virginia. He lived south of the James River in the area that is today Surry County. Chanco is the subject of a semi-historical story about him warning an English settler before a coordinated attack of the Powhatan Confederacy upon multiple locations in the Virginia Colony on March 22, 1622, …