Captain Nichola Kathleen Sarah Goddard MSM (May 2 1980 - May 17 2006) was the first female Canadian soldier killed in combat, and the 16th Canadian soldier killed in Canadian operations in Afghanistan.

Stephen McHattie Smith (born February 3, 1947 in Antigonish, Nova Scotia, Canada) is a Canadian actor. He is currently married to actress Lisa Houle, with whom he has three children. He was previously married to Meg Foster.

William Alexander Henry (December 30, 1816 - May 3, 1888) was a Canadian lawyer, politician, judge and one of the Fathers of Confederation. After service as a cabinet minister in Nova Scotia in governments led by both the Liberals and the Conservatives, Henry was a delegate to all three Confederation Conferences, and may have helped draft the "British North America Act", i.e., the Canadian constitution. He was appointed to the Supreme Court of Canada in 1875.

Dean Melanson (born November 19, 1973, in Antigonish, Nova Scotia, Canada) is a former National Hockey League defenseman. He was drafted in the fourth round, 80th overall, by the Buffalo Sabres in the 1992 NHL Entry Draft. Melanson appeared in only nine games in the NHL: five with the Sabres in the 1994-95 season and four with the Washington Capitals in the 2001-02 season. The majority of his professional career has been spent in the American Hockey League.

Dennis Kevin Bonvie (born July 23, 1973, in Antigonish, N.S.) is a Canadian ice hockey player who is currently a member of the Wilkes-Barre/Scranton Penguins of the American Hockey League.

Mark Day, (born October 4, 1978 in Antigonish, Nova Scotia) is a Canadian actor, writer and director.

Eileen O'Connell was a Canadian politician who served as a New Democratic Party member of the Nova Scotia Legislature for the constituency of Halifax Fairview from 1996 until her death in 2000. Eileen was born in 1947 and grew up in Antigonish, Nova Scotia. She was a graduate of St. Francis Xavier University, and attended both Dalhousie and St. Mary's Universities, where she earned a degree in Education. Eileen taught at Halifax West High School for 14 years, …

John Edward MacDonell, LL.B. (born September 29 1966) is Past President of the Progressive Conservative Association of Nova Scotia. He is the son of the late Dr. John MacDonell and Mrs. Antonia (Toni) MacDonell. After graduating from Dr. John Hugh Gillis Regional School, MacDonell earned a Bachelor of Arts degree from the University of King's College in Halifax in 1988, and a Bachelor of Laws degree from Dalhousie University in 1994.

Sir Joseph Andrew Chisholm (January 9, 1863 - January 22, 1950) was Mayor of Halifax and Chief Justice of the Supreme Court of Nova Scotia. Born in Maryvale, Nova Scotia to William and Flora Chisholm, Chisholm was educated at St. Francis Xavier University before moving to Halifax in 1896. He attended Dalhousie University where he received his law degree and his first job was in a law firm headed by a man destined to be a future Canadian Prime Minister, Robert Borden.

Carole MacNeil (born c. 1964 in Antigonish, Nova Scotia) is a television journalist with the Canadian Broadcasting Corporation. She is currently co-host with Evan Solomon of "CBC News: Sunday", a two-hour long weekly magazine program focusing on politics, ethics and spirituality. As of September 2004, MacNeil and Solomon have also been co-hosting "CBC News: Sunday Night", an hour-long prime time news broadcast on CBC Television and CBC Newsworld.

John Brophy (born January 20, 1933 in Antigonish, Nova Scotia) is a Canadian ice hockey coach and former hockey player who has spent most of his career in minor professional leagues, including 18 years as a player in the Eastern Hockey League and 13 seasons as a coach in the East Coast Hockey League. From 1986 to 1988 he was head coach of the Toronto Maple Leafs of the National Hockey League.

Alexander S. MacMillan (October 31, 1871 in Upper South River, Antigonish County -August 7, 1955) was a Nova Scotia politician and businessman. MacMillan made his fortune in lumbering and construction before being made chairman of the Nova Scotia Highways Board in 1920 and serving briefly as minister of highways in 1925. He was a member of Nova Scotia's appointed Upper House, …

Max Haines is a columnist. Haines was born in Antigonish, Nova Scotia. He began researching murders from around the world, past and present as a hobby. His "Crime Flashbbacks" column made its debut in the Toronto Sun in 1972. Since then, he has researched over 2000 crimes. Today "Crime Flashbacks" is syndicated across Canada and in several Latin and South American countries. Readership is over 3 million per week.

Ronald J. MacDonald is best known as the winner of the second Boston Marathon held in 1898.

Danny Graham is a lawyer and former politician in Nova Scotia, Canada. Born in Antigonish, Graham is the son of former senator Al Graham. Raised in Sydney, he attended St. Francis Xavier University where he earned the Blizzard Award and the Larkin Trophy for student achievement. He later earned his law degree at Dalhousie University. Graham worked in commercial, real estate, corporate and defence law and was an activist for the province's Restorative Justice programs, …

Edward Lavin Girroir (1871-08-26 - 1932-05-08) was a Nova Scotia politician. Born in 1871 in Tracadie, Nova Scotia, he was the son of William Girroir and Anne (Lavin) Girroir. He was a Halifax lawyer, and also lectured on international law at Saint Francis Xavier University in Antigonish, Nova Scotia. In 1900, 1905 and 1908, Girroir ran unsuccessfully for the Canadian House of Commons as a Conservative candidate in the federal riding of Antigonish.

Carroll Morgan is a former heavyweight boxer from Canada, who represented his native country at the 1972 Summer Olympics in Munich, West Germany. There he was defeated in the quarterfinals by Sweden's eventual bronze medalist Hasse Thomsén.

Craig MacDonald (born April 7, 1977 in Antigonish, Nova Scotia) is a Canadian professional ice hockey left winger who currently plays for the Tampa Bay Lightning in the National Hockey League.

Hugh F. Hanrahan BA, BEd, MEd (January 16 1947 - May 19 1999) was a member of the Canadian House of Commons for the Edmonton—Strathcona electoral district from 1993 to 1997. His career has been in education and writing. Hanrahan was born in Antigonish, Nova Scotia, where he would study arts and education at St. Francis Xavier University, then moved to Ottawa to obtain a Masters degree in education at the University of Ottawa.