- male, deceased (1676)
- Captain Elizur Holyoke (c. 1624 - 1676) was the namesake of the mountain, Mount Holyoke, and (indirectly), of the city of Holyoke, Massachusetts.
- male, deceased (1829)
- Edward Augustus Holyoke (August 1, 1728-March 31, 1829) was an educator and physician. A son of the Reverend Edward Holyoke, a former President of...
- male, deceased (1769)
- Edward Holyoke (June 26, 1689 - June 1, 1769) was an early American clergyman and educator. He studied at Harvard College (B.A., 1705; M.A., 1708)...
- male, deceased (1820)
- Samuel Adams Holyoke was the son of Rev. Elizur Holyoke and Hannah Peabody. He was born on 15 October 1762 in Boxford, Massachusetts, in Essex...
- male, 66 years old
- William Wegman (b. 1943 in Holyoke, Massachusetts) is an artist best known for creating series of compositions involving dogs, primarily his own...
- male
- Michael R. Knapik is a member of the Massachusetts Senate, representing the 2nd Hampden and Hampshire District. He is a member of the United States...
- male, 46 years old
- Arthur "Art" Adams, born in 1963 in Holyoke, Massachusetts, is an American writer and comic book illustrator. Adams from his childhood dreamed of...
- male, 64 years old
- Gary Hallgren (born October 28, 1945) is an American illustrator and underground cartoonist. Growing up in the U.S. Pacific Northwest, he studied...
- male, deceased (1988)
- John Clellon Holmes (March 12, 1926 - March 2, 1988), born in Holyoke Massachusetts, was a writer, poet and professor, best known for his 1952 book...
- male, deceased (1890)
- Junius Spencer Morgan was an American banker and financier, born at West Springfield (now Holyoke), Massachusetts.
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